The Operation game features classic gameplay where players take on the role of a doctor performing "surgery" on Cavity Sam. Using tweezers, players carefully remove various ailment pieces from the game board without touching the edges of the cavities. If the tweezers make contact with the sides, a buzzer sounds and Cavity Sam’s nose lights up. Players earn money for each successful removal, and the winner is the one with the highest total at the end. The game can be played solo or with multiple players, making it suitable for individual or group play. Designed for ages 6 and up, it serves as an engaging gift option for birthdays or holidays. The gameplay emphasizes skill, coordination, and lighthearted fun.